Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, morphine, and many others. Detoxification and treatment of opioid addiction has benefitted greatly by use of medications such as buprenorphine, naltrexone, and methadone, but they remain highly underutilized. Though fentanyl is approved to treat severe pain related to surgery, over the past decade it has been manufactured and distributed illegally (IMF) and, according to federal data, was responsible for 64 percent of deaths attributed to opioids. Many people are exposed to fentanyl without knowledge while others use it intentionally because of its potency. And recently, Xylazine, a non-opioid veterinary tranquilizer not approved for human use has been linked to an increasing number of overdose deaths nationwide. Studies show people exposed to xylazine often knowingly or unknowingly used it in combination with other drugs, particularly illicit fentanyl.